Have my Sony Vaio laptop running Windows 8 with two USB hubs. And I have both 23″ monitors, HDMI port, and DVI to USB set up. I have the laptop lid closed, so only the two external monitors are visible.
Using old Acer wireless keyboard and right handed Acer wireless mouse, and my lefty mouse. Have my graphics tablet on top of the closed laptop.
As I said, it ain’t pretty, but it works.